Diazepam is highly lipid-soluble, and it is greatly distributed throughout the human body just after administration. It quickly crosses the two the blood–Mind barrier as well as placenta, and is particularly excreted into breast milk.

On account of lengthy-performing metabolite, not regarded a drug of alternative during the elderly; related to falls

Aged and really unwell sufferers can perhaps expertise apnea or cardiac arrest. Concomitant utilization of other central anxious program depressants increases this chance. The smallest possible helpful dose must be useful for this group of people.[59][sixty] The aged metabolise benzodiazepines a lot more slowly and gradually than young Grownups, and also are more delicate to the results of benzodiazepines, even at related blood plasma degrees.

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diazepam increases toxicity of oliceridine by Other (see comment). Modify Therapy/Watch Closely. Remark: Anticholinergic drugs might increase threat of urinary retention and/or critical constipation, which can bring about paralytic ileus.

Diazepam may interfere with metabolism of substrates for CYP2C19 and CYP3A4 leading to a potential drug-drug interaction

stiripentol will lessen the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Carefully. Take into consideration lowering the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.

Clear away the patch and get health-related help right away When you've got any incredibly major Unintended effects, including: eye suffering/swelling/redness, eyesight modifications (including observing rainbows all-around lights at nighttime), seizures.

The above mentioned information is provided for typical informational and academic purposes only. Particular person ideas may well fluctuate and formulary info alterations. Speak to the applicable strategy service provider for one of the most present-day facts.

benzhydrocodone/acetaminophen and diazepam both equally enhance sedation. Stay away from or Use Alternate Drug. Limit use to individuals for whom alternate treatment method choices are insufficient

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ethinylestradiol will improve the stage or influence of diazepam by Mechanism: decreasing metabolism. Use Warning/Watch. Ethinyl estradiol may perhaps inhibit the clearance of benzodiazepines that undertake oxidation, thus rising serum concentrations of concomitantly administered benzodiazepines.

acetazolamide will enhance the degree or influence of diazepam by influencing hepatic/intestinal enzyme apihp drug CYP3A4 metabolism. Insignificant/Significance Mysterious.

marijuana will increase the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.